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"The process for translating basic science discoveries into clinical applications has historically involved a linear and lengthy progression from initial discovery to preclinical testing, regulatory evaluation and approval, and, finally, use in clinical practice. The low rate of translation from basic science to clinical application has been a source of frustration for many scientists, clinicians, investors, policy makers, and patients who hoped that investments in research would result in improved products and processes for patients. Some feel that the anticipated deliverables from the Human Genome Project have not yet materialized, and although understanding of human health and disease biology has increased, there has not been a concomitant increase in the number of approved drugs for patients over the past 10 years. Improving the Efficiency and Effectiveness of Genomic Science Translation is the summary of a workshop convened by the Institute of Medicine Roundtable on Translating Genomic-Based Research for Health in December 2012 to explore ways to improve the efficiency and effectiveness of the translation of genomic science to clinical practice. The workshop convened academic researchers, industry representatives, policy makers, and patient advocates to explore obstacles to the translation of research findings to clinical practice and to identify opportunities to support improvement of the early stages of the process for translation of genetic discoveries. This report discusses the realignment of academic incentives, the detection of innovative ways to fund translational research, and the generation or identification of alternative models that accurately reflect human biology or disease to provide opportunities to work across sectors to advance the translation of genomic discoveries" --

Medical care --- Genomics --- Genetics --- Computational Biology --- Biology --- Biological Science Disciplines --- Natural Science Disciplines --- Disciplines and Occupations --- Health & Biological Sciences --- Research

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How do we know whether a particular treatment really works? How reliable is the evidence? And how do we ensure that research into medical treatments best meets the needs of patients? These are just a few of the questions addressed in a lively and informative way in Testing Treatments. Brimming with vivid examples, Testing Treatments will inspire both patients and professionals. Building on the success of the first edition, Testing Treatments has now been extensively revised and updated. The second edition includes a thought-provoking chapter on screening, explaining why early diagnosis is no

Science --- Medicine --- Natural Science Disciplines --- Health Occupations --- Disciplines and Occupations --- Clinical Medicine --- Research --- Health & Biological Sciences --- Medical Research

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Fluids --- Molecular theory --- Chemistry, Physical --- Chemistry --- Natural Science Disciplines --- Disciplines and Occupations --- congresses. --- Congresses. --- Fluids. --- Molecular dynamics. --- Chemical chains --- Interface --- Magnetic relaxation --- Quantum mechanics --- Thermodynamics --- Water

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Endodontics -- methods. --- Endodontics. --- Publication Formats --- Specialties, Dental --- Dentistry --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Publication Characteristics --- Health Occupations --- Disciplines and Occupations --- Endodontics --- Atlases --- Health & Biological Sciences --- Dentistry - General --- Dental pulp --- Endodontie --- Pulpe dentaire --- Atlases. --- Diseases. --- Maladies --- Endodontia --- Endodontists --- Diseases

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In the past decade, there has been an explosion of progress in understanding the roles of carbohydrates in biological systems. This explosive progress was made with the efforts in determining the roles of carbohydrates in immunology, neurobiology and many other disciplines, examining each unique system and employing new technology. This volume represents the second of three in the Methods in Enzymology series, including Glycobiology (vol. 415) and Functional Glycomics (vol. 417), dedicated to disseminating information on methods in determining the biological roles of carbohydrates. Thes

Carbohydrates. --- Proteins. --- Genetics --- Computational Biology --- Chemicals and Drugs --- Amino Acids, Peptides, and Proteins --- Biology --- Biological Science Disciplines --- Natural Science Disciplines --- Disciplines and Occupations --- Genomics --- Proteins --- Carbohydrates --- Proteids --- Carbs (Carbohydrates) --- Biomolecules --- Polypeptides --- Proteomics --- Organic compounds --- Glycomics